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Recommended Screening Guidelines
Although age 50 has traditionally been the age for starting to consider PSA testing, researchers have recognized that high-risk groups such as African Americans and men with family histories of prostate cancer may benefit from beginning screening at an earlier age.
The 2009 National Comprehensive Cancer Network (NCCN) Prostate Cancer Early Detection Guidelines indicate that men may need to have a baseline PSA test as early as age 40 to assess their risk for subsequent prostate cancer detection. The decision to participate in an early detection program for prostate cancer should be discussed with your doctor.
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reconciling biopsy results with final pathology
I think this is of some interest. My 12 needle biopsy came back with one of the needle cores testing positive. Of this one core, 20% of it was cancerous, with a gleason of 3+4. But when the final biopsy of my surgically removed prostate was performed, it was determined 42% cancerous. My doctor said that it was a good thing that I had surgery when I did, while it was still encapsulated.
Later I researched this discrepancy and found articles re the fact that the initial biopsy is often 1 gleason underscored.
Just a word in relationship
Just a word in relationship to your comment. My biopsy had a gleason score of 8, and after surgery to remove prostate it was determined to be 4+3.